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Alright, let's start with the basics: Who *was* Joko Tingkir, exactly? Joko Tingkir, also known as Sultan Hadiwijaya, was a prominent figure in 16th-century Java, particularly during the era of the Demak Sultanate and the rise of the Pajang Sultanate. He was a *powerful ruler* known for his military prowess, wisdom, and strong adherence to Islamic values. Born with the name Raden Mas Karebet, he later became known as Joko Tingkir, a name that stuck with him throughout his life. He was a student of Sunan Giri, one of the famous Wali Songo (nine saints) who played a pivotal role in spreading Islam in Java. His journey was marked by challenges, including navigating the complex political landscape of the time, and ultimately establishing his own kingdom.
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Karena *intron DNA* sangat krusial untuk proses *splicing* yang benar, mutasi (perubahan) pada intron bisa mengganggu proses ini. Mutasi ini bisa terjadi pada situs *splicing* (tempat di mana intron seharusnya dipotong) atau di area lain dalam intron yang mempengaruhi pengenalan situs *splicing*. Akibatnya, *splicing* bisa berjalan tidak benar. Bisa jadi intron tidak terbuang sepenuhnya, atau ekson terbuang bersama intron (disebut *exon skipping*), atau bahkan urutan *splicing* yang baru terbentuk.
