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The *GNAS* gene is located on chromosome 20. If something goes wrong with the *GNAS* gene, especially in the part of the gene that affects the PTH receptor, it can lead to PPHP. This 'something going wrong' can be a mutation or a change in the DNA sequence. This change affects how cells respond to the PTH hormone. Depending on the exact genetic change and which copy of the *GNAS* gene is affected, different conditions can arise. For instance, if the *GNAS* gene mutation is inherited from the mother, it's more likely to cause Albright's hereditary osteodystrophy (AHO), which often includes PPHP alongside other problems. If the *GNAS* gene mutation is inherited from the father, it may result in PHP, which can lead to low calcium, high phosphate levels, and potential health complications. The inheritance pattern of PPHP is typically autosomal dominant, meaning that if one parent has the gene mutation, there's a 50% chance their child will inherit it. But don't worry, genetic counseling can provide a much clearer picture based on your specific family situation and can help you navigate the complexities of genetic inheritance.
